Knowledge is power and having information eliminates unnecessary stresses in life. Gone are the days when men would shy away due to poor sexual performance, which has been solved by the development of great products such as the caverta 100mg tablets. Read on to discover more.
Caverta; the New Male Enhancement Solution
Caverta is a film-coated tablet containing sildenafil citrate as the active ingredient. It is used as an oral therapy in the management of erectile dysfunction. This compound selectively inhibits the action of phosphodiesterase type 5 enzymes in a process that leads to better erections and reduced premature orgasm.
How Does It Work?
Sexual stimulation causes release of nitric oxide. Sildenafil citrate causes inhibition of phosphodiesterase enzyme leading to higher levels of cGMP in the penile tissue. This further causes relaxation of the smooth muscles and blood flow into the penis. It is important to note that caverta will show best action in the presence of sexual stimulation.
Effects of Other Medications on Caverta
Research has been done on interactions of caverta with other medications. According to in vitro studies conducted, the metabolism of sildenafil is controlled by a cytochrome P450, with isoforms 3A4 as the major route and 2C9 as the minor route. Any compound that affects the activity of these isoenzymes will interfere with action of sildenafil citrate.
In Vivo Research on Drug Interactions with Caverta
Research has shown that interaction with some compounds inside the body will cause increased levels of sildenafil in the plasma. Cimetidine, which is a CYP inhibitor, causes an increase of 56% of sildenafil in the plasma. Ethromycin (CYP3A4 inhibitor) caused a 182% increase in sildenafil internal exposure. Antacids such a magnesium and aluminum hydroxides do not have any impact on the bioavailability of sildenafil.
Findings from Pharmacokinetic Data on Caverta Use
Data obtained from clinical trials showed no significant effect of other inhibitors on the action of sildenafil. These include tolbutamide, warfarin (CYP2C9 pathways inhibitors) and serotonin uptake inhibitors. The interactions are not detrimental or such as to limit the use of caverta.
Use of Caverta on Other Drugs
The active ingredient of caverta is a low inhibitor of cytochrome p450 isoforms. Its total plasma concentration is approximately 1mm, therefore highly unlikely that it will interfere with the activity of any other enzymes in the body. In vivo research shows a mild effect on hypertensive patients using amlodipine medication.
Are There Any Effects on Over Dosage?
According to research, the effects of over dosage are similar to side effects occurring in a healthy person. The excess can be excreted through the renal system and the user should seek medical advice when unusual symptoms occur.
Marketing and Supply of Caverta
Online pharmacies and medical sites have been very instrumental in dissemination of information about the benefits of caverta medicine. It is available as caverta 100mg tablets and doctor’s advice is recommended before taking the medication.
The management of erectile dysfunction has become much easier with the development of medications such as the caverta tablets. Research has shown insignificant interaction with other medications apart from nitrates and mild side effects.
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